China Airlines Flight 642 was a flight that crashed at Hong Kong (Chek Lap Kok) International Airport on 22 August 1999. It was operating from Bangkok (Bangkok International Airport, now renamed as Don Mueang International Airport) to Taipei with a stopover in Hong Kong.

The plane, a McDonnell Douglas MD-11 (registration B-150), touched down hard during landing, flipped over and caught fire. Of the 315 people on board, 312 survived and three were killed. It was the first fatal accident to occur at the new Hong Kong International airport since it opened in July 1998.

Flight 642 was one of only two hull losses of MD-11s with passenger configuration, the other being Swissair Flight 111, which crashed in 1998 with 229 fatalities.